产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4562, RRID:AB_2836913.
展开/折叠
Acute morphine dependence related protein 2; Amino acid transport defect complementing; CCT zeta 1; CCT zeta; CCT-zeta; CCT-zeta-1; CCT6; CCTZ; Chaperonin containing T complex subunit 6; Chaperonin containing TCP1 subunit 6A; Chaperonin containing TCP1 subunit 6A (zeta 1); Histidine transport regulator 3; HTR3; MGC126214; MGC126215; MoDP 2; MoDP-2; MoDP2; T complex protein 1 subunit zeta; T complex protein 1 zeta subunit; TCP 1 zeta; TCP-1-zeta; TCP1 zeta; TCP20; TCPZ; TTCP20;
抗原和靶标
- P40227 TCPZ_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P40227 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K5 | Acetylation | Uniprot | |
| K5 | Methylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Sumoylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| R35 | Methylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| T120 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K199 | Acetylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| Y239 | Phosphorylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| K280 | Acetylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K287 | Acetylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K295 | Acetylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| R314 | Methylation | Uniprot | |
| K365 | Acetylation | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| K377 | Acetylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| K388 | Acetylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| R396 | Methylation | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| C406 | S-Nitrosylation | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| K530 | Ubiquitination | Uniprot |
研究背景
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Cytoplasm.
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.
Belongs to the TCP-1 chaperonin family.
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