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| 产品: | TCF7L1 抗体 |
| 货号: | DF4573 |
| 描述: | Rabbit polyclonal antibody to TCF7L1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 63 KD; 63kD(Calculated). |
| 蛋白号: | Q9HCS4 |
| RRID: | AB_2836924 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4573, RRID:AB_2836924.
展开/折叠
bHLHb21; HMG box transcription factor 3; HMG box transcription factor; OTTMUSP00000023419; T cell factor 3; TCF 3; TCF-3; TCF3; Tcf7l1; TF7L1_HUMAN; Transcription factor 7 like 1 (T-cell specific, HMG-box); Transcription factor 7 like 1; Transcription factor 7-like 1;
抗原和靶标
Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
- Q9HCS4 TF7L1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9HCS4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S171 | Phosphorylation | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| K358 | Acetylation | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| K363 | Acetylation | Uniprot | |
| K394 | Ubiquitination | Uniprot | |
| Y395 | Phosphorylation | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| T495 | Phosphorylation | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot |
研究背景
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Nucleus.
Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
Binds the armadillo repeat of CTNNB1 and forms a stable complex.
The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
Belongs to the TCF/LEF family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Colorectal cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Endometrial cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Prostate cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Thyroid cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Breast cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Organismal Systems > Endocrine system > Melanogenesis.
文献引用
Application: WB Species: Rat Sample: Atrial tissue
Application: WB Species: rat Sample: atria
Application: WB Species: rat Sample: atria
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