产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4609, RRID:AB_2836973.
展开/折叠
MMDS3; MVti1; SNARE Vti1a beta protein; Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport through interaction with tSNAREs homolog 1A (yeast); Vesicle transport v-SNARE protein Vti1-like 2; Vti1 rp2; Vti1-rp2; Vti1a; VTI1A vesicle transport through interaction with t-SNAREs 1A; VTI1A_HUMAN; VTI1RP2;
抗原和靶标
- Q96AJ9 VTI1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRILTGMLRRIIQNRILLVILGIIVVITILMAITFSVRRH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96AJ9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| Y95 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| T122 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | Uniprot | |
| T170 | Phosphorylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot |
研究背景
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.
Cytoplasmic vesicle. Golgi apparatus membrane>Single-pass type IV membrane protein.
Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.
Belongs to the VTI1 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
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