| 产品: | VTI1B 抗体 |
| 货号: | DF4610 |
| 描述: | Rabbit polyclonal antibody to VTI1B |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 27 KD; 27kD(Calculated). |
| 蛋白号: | Q9UEU0 |
| RRID: | AB_2836974 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4610, RRID:AB_2836974.
展开/折叠
HGNC:17793; V SNARE; v-SNARE; Vesicle associated soluble NSF attachment protein receptor; Vesicle transport through interaction with t SNAREs 1B; Vesicle transport through interaction with t SNAREs homolog 1B (yeast); Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; VTI1; VTI1 like; Vti1 rp1; VTI1-LIKE; Vti1-rp1; VTI1B; VTI1B_HUMAN; VTI1L; VTI1L1; VTI2;
抗原和靶标
- Q9UEU0 VTI1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASSAASSEHFEKLHEIFRGLHEDLQGVPERLLGTAGTEEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRNYRKDLAKLHREVRSTPLTATPGGRGDMKYGIYAVENEHMNRLQSQRAMLLQGTESLNRATQSIERSHRIATETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIIILLELAILGGLVYYKFFRSH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UEU0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| T103 | Phosphorylation | Uniprot | |
| R107 | Methylation | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| T154 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S185 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot |
研究背景
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
Early endosome membrane>Single-pass type IV membrane protein. Late endosome membrane>Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule. Recycling endosome membrane>Single-pass type IV membrane protein.
Expressed in all tissues examined.
Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17. Interacts with CLINT1.
Belongs to the VTI1 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
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