产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4619, RRID:AB_2836983.
展开/折叠
KIAA0900; Protein WAVE-3; Protein WAVE3; SCAR3; Verprolin homology domain containing protein 3; Verprolin homology domain-containing protein 3; WASF3; WASF3_HUMAN; WASP family protein member 3; WAVE3; Wiskott Aldrich syndrome protein family member 3; Wiskott-Aldrich syndrome protein family member 3;
抗原和靶标
- Q9UPY6 WASF3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNRPQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSDDDSEFDENDWSD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UPY6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y151 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y156 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| Y248 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y286 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y486 | Phosphorylation | P00519 (ABL1) | Uniprot |
研究背景
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.
Cytoplasm>Cytoskeleton.
Expressed in ovary and brain.
Binds actin and the Arp2/3 complex.
Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Belongs to the SCAR/WAVE family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
限制条款
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