| 产品: | ADCY9 抗体 |
| 货号: | DF4649 |
| 描述: | Rabbit polyclonal antibody to ADCY9 |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 150 KD; 151kD(Calculated). |
| 蛋白号: | O60503 |
| RRID: | AB_2837000 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4649, RRID:AB_2837000.
展开/折叠
ADCY 9; ADCY9; ADCY9_HUMAN; Adenylate cyclase 9; Adenylate cyclase type 9; Adenylate cyclase type IX; Adenylyl cyclase 9; ATP pyrophosphate lyase 9; ATP pyrophosphate-lyase 9; KIAA0520; Type IX adenylyl cyclase; Type IX ATP pyrophosphate lyase;
抗原和靶标
Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952).
- O60503 ADCY9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
翻译修饰 - O60503 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S25 | Phosphorylation | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S56 | Phosphorylation | Uniprot | |
| Y122 | Phosphorylation | Uniprot | |
| Y133 | Phosphorylation | Uniprot | |
| Y172 | Phosphorylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K330 | Acetylation | Uniprot | |
| K348 | Acetylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| T363 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| T494 | Phosphorylation | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| K564 | Ubiquitination | Uniprot | |
| T608 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| S611 | Phosphorylation | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| K628 | Ubiquitination | Uniprot | |
| S632 | Phosphorylation | Uniprot | |
| K671 | Ubiquitination | Uniprot | |
| S678 | Phosphorylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| S691 | Phosphorylation | Uniprot | |
| K699 | Ubiquitination | Uniprot | |
| S706 | Phosphorylation | Uniprot | |
| K723 | Ubiquitination | Uniprot | |
| K773 | Ubiquitination | Uniprot | |
| K1098 | Ubiquitination | Uniprot | |
| T1109 | Phosphorylation | Uniprot | |
| S1212 | Phosphorylation | Uniprot | |
| S1217 | Phosphorylation | Uniprot | |
| K1218 | Ubiquitination | Uniprot | |
| Y1221 | Phosphorylation | Uniprot | |
| Y1225 | Phosphorylation | Uniprot | |
| S1257 | Phosphorylation | Uniprot | |
| S1259 | Phosphorylation | Uniprot | |
| S1269 | Phosphorylation | Uniprot | |
| K1302 | Ubiquitination | Uniprot | |
| S1307 | Phosphorylation | Uniprot | |
| K1330 | Ubiquitination | Uniprot | |
| K1346 | Ubiquitination | Uniprot | |
| S1350 | Phosphorylation | Uniprot | |
| S1352 | Phosphorylation | Uniprot |
研究背景
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors.
Cell membrane>Multi-pass membrane protein.
Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta. Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
研究领域
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Substance dependence > Morphine addiction.
· Human Diseases > Infectious diseases: Bacterial > Vibrio cholerae infection.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > GABAergic synapse.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Ovarian steroidogenesis.
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Endocrine system > Relaxin signaling pathway.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
限制条款
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