| 产品: | SLC38A2 抗体 |
| 货号: | DF4673 |
| 描述: | Rabbit polyclonal antibody to SLC38A2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Horse, Rabbit, Dog |
| 分子量: | 50 KD; 56kD(Calculated). |
| 蛋白号: | Q96QD8 |
| RRID: | AB_2837024 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4673, RRID:AB_2837024.
展开/折叠
Amino acid transporter 2; Amino acid transporter A2; ATA2; KIAA1382; PRO1068; Protein 40-9-1; S38A2_HUMAN; SAT2; Slc38a2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Solute carrier family 38 member 2; System A amino acid transporter; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2;
抗原和靶标
Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
- Q96QD8 S38A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96QD8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K2 | Ubiquitination | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| Y28 | Phosphorylation | Uniprot | |
| Y30 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K38 | Methylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| Y134 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| Y217 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot |
研究背景
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
Cell membrane>Multi-pass membrane protein.
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.
Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
Belongs to the amino acid/polyamine transporter 2 family.
研究领域
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Nervous system > GABAergic synapse.
· Organismal Systems > Digestive system > Protein digestion and absorption.
限制条款
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