ARX Antibody - #DF4674

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产品: ARX 抗体
货号: DF4674
描述: Rabbit polyclonal antibody to ARX
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Sheep, Rabbit, Dog
分子量: 55 KD; 58kD(Calculated).
蛋白号: Q96QS3
RRID: AB_2837025

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Sheep(100%), Rabbit(91%), Dog(100%)
克隆:
Polyclonal
特异性:
ARX Antibody detects endogenous levels of total ARX.
RRID:
AB_2837025
引用格式: Affinity Biosciences Cat# DF4674, RRID:AB_2837025.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Aristaless related homeobox gene; Aristaless-related homeobox; Arx; ARX_HUMAN; Homeobox protein ARX; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRXS1; phox2a; PRTS;

抗原和靶标

免疫原:
Uniprot:

Q96QS3(ARX_HUMAN) >>Visit HPA database.

基因/基因ID:
ARX(170302)
表达:
Q96QS3 ARX_HUMAN:

Expressed predominantly in fetal and adult brain and skeletal muscle. Expression is specific to the telencephalon and ventral thalamus. There is an absence of expression in the cerebellum throughout development and also in adult.

序列:
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLTSRADPEKAVQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATAGPRGEAPPPPPPTARPGERPDGAGAAAAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVTHPEERLGVAGGPGSAPAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCPVAATGAVAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Sheep
100
Dog
100
Rabbit
91
Xenopus
78
Horse
0
Bovine
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q96QS3 作为底物

Site PTM Type Enzyme
R86 Methylation
R87 Methylation
Y89 Phosphorylation
R122 Methylation
S486 Phosphorylation

研究背景

功能:

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed predominantly in fetal and adult brain and skeletal muscle. Expression is specific to the telencephalon and ventral thalamus. There is an absence of expression in the cerebellum throughout development and also in adult.

蛋白家族:

Belongs to the paired homeobox family. Bicoid subfamily.

文献引用

1). In utero exposure to phenanthrene induced islet cell dysfunction in adult mice: sex differences in the effects and potential causes. Science of The Total Environment, 2021 (PubMed: 33513515) [IF=9.8]

Application: WB    Species: mice    Sample: islet cell

Fig. 4. The expression of pancreatic proteins that participate in islet cell function of adult F1 mice. The data were shown as the mean ± SE and analyzed with SPSS 19.0 software. Significant difference (p < 0.05) was tested using one-way ANOVA (Duncan's test), which are labeled by *. n = 4, 3 dams from each group, and 1–2 F1 mice from each dam.
2). Exposure to Aroclor 1254 differentially affects the survival of pancreatic β-cells and α-cells in the male mice and the potential reason. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020 (PubMed: 31706244) [IF=6.8]

Application: IF/ICC    Species: mouse    Sample: islet cell

Fig. 6.| Immunofluorescence analysis of Pdx1 and Arx expression in islet cells of male mice exposed to Aroclor 1254 for 60 days. (A) Representative images of triple staining for insulin (green), Pdx-1 (red), and DAPI (blue) on fixed, paraffin-embedded pancreas sections. (B) Percentage of Pdx-1 positive data are presented as mean ± SE (n = 3). (C) Representative images of triple staining for glucagon (green), Arx (red), and DAPI (blue) on fixed, paraffin-embedded pancreas sections. (D)Percentage of Arx positive data are presented as mean ± SE (n = 3). Means of exposures not sharing a common letter are significantly different at P < 0.05 as assessed by one-way ANOVA followed by the Duncan test. Scale bar = 50 μm.

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