| 产品: | TEAD3 抗体 |
| 货号: | DF4677 |
| 描述: | Rabbit polyclonal antibody to TEAD3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 49 KD; 49kD(Calculated). |
| 蛋白号: | Q99594 |
| RRID: | AB_2837028 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4677, RRID:AB_2837028.
展开/折叠
DTEF 1; DTEF-1; DTEF1; ETFR 1; ETFR1; TEA domain family member 3; TEA domain family member 5; TEAD 3; TEAD-3; Tead3; TEAD3_HUMAN; TEAD5; TEF 5; TEF5; Transcriptional enhancer factor 5; Transcriptional enhancer factor TEF 5 (DTEF 1); Transcriptional enhancer factor TEF 5; Transcriptional enhancer factor TEF-5;
抗原和靶标
- Q99594 TEAD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q99594 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K83 | Methylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| K279 | Acetylation | Uniprot | |
| K283 | Acetylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| Y350 | Phosphorylation | Uniprot |
研究背景
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Nucleus.
Preferentially expressed in the placenta.
Interacts with YAP1 and WWTR1/TAZ.
研究领域
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species. (View pathway)
限制条款
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