| 产品: | IL17RC 抗体 |
| 货号: | DF4708 |
| 描述: | Rabbit polyclonal antibody to IL17RC |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 分子量: | 70 KD; 86kD(Calculated). |
| 蛋白号: | Q8NAC3 |
| RRID: | AB_2837059 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4708, RRID:AB_2837059.
展开/折叠
IL 17 receptor C; IL 17RC; IL 17RL; IL17 receptor C; IL17F receptor; IL17RL; Interleukin 17 receptor C; Interleukin 17 receptor homolog; Interleukin 17 receptor like; Interleukin 17 receptor like protein;
抗原和靶标
Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037).
- Q8NAC3 I17RC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPVSLEPWGDEERLRVQFLAQQSLSLAPVTAATARTALSGLSGADGRREERGRGKSWVCLSLGGSGNTEPQKKGLSCRLWDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKRWALVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGAAARGRAALLLYSADDSGFERLVGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQRRQTLQEGGVVVLLFSPGAVALCSEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFDRLLHPDAVPALFRTVPVFTLPSQLPDFLGALQQPRAPRSGRLQERAEQVSRALQPALDSYFHPPGTPAPGRGVGPGAGPGAGDGT
翻译修饰 - Q8NAC3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y252 | Phosphorylation | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| K572 | Ubiquitination | Uniprot | |
| T772 | Phosphorylation | Uniprot |
研究背景
Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1.
Receptor for both IL17A and IL17F.
Does not bind IL17A or IL17F.
Does not bind IL17A or IL17F.
Receptor for both IL17A and IL17F.
Cell membrane>Single-pass type I membrane protein.
Note: Soluble isoforms may be produced.
Expressed in prostate, skeletal muscle, kidney and placenta (at protein level). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Also detected in thyroid, trachea and adrenal gland. Low expression in thymus and leukocytes.
Heterodimer with IL17RA. Heterodimerization with IL17RA is independent of the cytoplasmic tail (By similarity). Associates with non-glycosylated IL17RA constitutively (By similarity). Binding of IL17A and IL17F induces association with glycosylated IL17RA (By similarity). Interacts (via SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (By similarity).
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
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