产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4717, RRID:AB_2837068.
展开/折叠
Cardiac myosin light chain 1; CMH8; CMLC1; ELC of myosin; Essential light chain of myosin; MLC1SB; MLC1V; MYL3; MYL3_HUMAN; Myosin light chain 1; Myosin light chain 1 slow twitch muscle B/ventricular isoform; Myosin light chain 1 slow, B; Myosin light chain 3; Myosin, light chain 1, ventricular; myosin, light chain 3, alkali; ventricular, skeletal, slow; myosin, light polypeptide 3, alkali; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow; OTTHUMP00000165922; Slow skeletal ventricular myosin alkali light chain 3; slow-twitch muscle B/ventricular isoform; Ventricular/slow twitch myosin alkali light chain; VLC1;
抗原和靶标
- P08590 MYL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPKKPEPKKDDAKAAPKAAPAPAPPPEPERPKEVEFDASKIKIEFTPEQIEEFKEAFMLFDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMSS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08590 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Methylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| Y73 | Phosphorylation | Uniprot | |
| T88 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K125 | Acetylation | Uniprot | |
| T127 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| Y130 | Phosphorylation | Uniprot | |
| K142 | Acetylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| Y185 | Phosphorylation | Uniprot |
研究背景
Regulatory light chain of myosin. Does not bind calcium.
The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
Myosin is a hexamer of 2 heavy chains and 4 light chains.
研究领域
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
限制条款
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