产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4807, RRID:AB_2837100.
展开/折叠
CD_antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; syndecan proteoglycan 1; Syndecan-1;
抗原和靶标
- P18827 SDC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P18827 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T61 | O-Glycosylation | Uniprot | |
| T72 | O-Glycosylation | Uniprot | |
| T76 | O-Glycosylation | Uniprot | |
| S77 | O-Glycosylation | Uniprot | |
| T81 | O-Glycosylation | Uniprot | |
| T122 | O-Glycosylation | Uniprot | |
| T164 | O-Glycosylation | Uniprot | |
| S165 | O-Glycosylation | Uniprot | |
| T166 | O-Glycosylation | Uniprot | |
| S171 | O-Glycosylation | Uniprot | |
| T177 | O-Glycosylation | Uniprot | |
| T180 | O-Glycosylation | Uniprot | |
| S186 | O-Glycosylation | Uniprot | |
| T188 | O-Glycosylation | Uniprot | |
| T240 | O-Glycosylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| Y299 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| Y309 | Phosphorylation | Uniprot |
研究背景
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Membrane>Single-pass type I membrane protein. Secreted. Secreted>Extracellular exosome.
Note: Shedding of the ectodomain produces a soluble form.
Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity).
Belongs to the syndecan proteoglycan family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Malaria.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
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