| 产品: | PE2R4 抗体 |
| 货号: | DF4880 |
| 描述: | Rabbit polyclonal antibody to PE2R4 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 55 KD; 53kD(Calculated). |
| 蛋白号: | P35408 |
| RRID: | AB_2837172 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4880, RRID:AB_2837172.
展开/折叠
EP 4; EP4; EP4R; MGC126583; PE2R4_HUMAN; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostaglandin E receptor 4; Prostaglandin E receptor 4 subtype EP4; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER 2; PTGER 4; PTGER2; PTGER4;
抗原和靶标
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
- P35408 PE2R4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P35408 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S222 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| S484 | Phosphorylation | Uniprot |
研究背景
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
Cell membrane>Multi-pass membrane protein.
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Interacts with FEM1A.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
· Organismal Systems > Endocrine system > Renin secretion.
限制条款
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