| 产品: | RRM2B 抗体 |
| 货号: | DF4826 |
| 描述: | Rabbit polyclonal antibody to RRM2B |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Sheep, Dog |
| 分子量: | 40 KD; 41kD(Calculated). |
| 蛋白号: | Q7LG56 |
| RRID: | AB_2837191 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4826, RRID:AB_2837191.
展开/折叠
DKFZp686M05248; MGC102856; MGC42116; MTDPS8A; MTDPS8B; p53 inducible ribonucleotide reductase small subunit 2 homolog; p53 inducible ribonucleotide reductase small subunit 2 like protein; P53 inducible ribonucleotide reductase small subunit 2 short form beta; p53 R2; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; Ribonucleoside diphosphate reductase M2 subunit B; Ribonucleoside-diphosphate reductase subunit M2 B; Ribonucleotide reductase M2 B (TP53 inducible); Ribonucleotide reductase M2 B; Ribonucleotide reductase small subunit like 2 p53 inducible; RIR2B_HUMAN; RRM 2B; RRM2B; TP53 inducible ribonucleotide reductase M2 B; TP53-inducible ribonucleotide reductase M2 B;
抗原和靶标
Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.
- Q7LG56 RIR2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q7LG56 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R17 | Methylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| S72 | Phosphorylation | Q13315 (ATM) | Uniprot |
| K166 | Ubiquitination | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| K326 | Acetylation | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| Y331 | Phosphorylation | Uniprot |
研究背景
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Cytoplasm. Nucleus.
Note: Translocates from cytoplasm to nucleus in response to DNA damage.
Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.
Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage.
Belongs to the ribonucleoside diphosphate reductase small chain family.
研究领域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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