ADORA3 Antibody - #DF4851

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产品: ADORA3 抗体
货号: DF4851
描述: Rabbit polyclonal antibody to ADORA3
应用: WB IHC IF/ICC
反应: Human, Mouse
分子量: 38 KD; 36kD(Calculated).
蛋白号: P0DMS8
RRID: AB_2837215

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
ADORA3 Antibody detects endogenous levels of total ADORA3.
RRID:
AB_2837215
引用格式: Affinity Biosciences Cat# DF4851, RRID:AB_2837215.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A3AR; A3R; AA3R; AA3R_HUMAN; AD 026; AD026; Adenosine A3 receptor; Adenosine receptor A3; ADORA 3; ADORA3; ARA3; bA552M11.5; Gpcr2; RP11 552M11.7; TGPCR1;

抗原和靶标

免疫原:
Uniprot:

P0DMS8(AA3R_HUMAN) >>Visit HPA database.

基因/基因ID:
ADORA3(140)
表达:
P0DMS8 AA3R_HUMAN:

Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

序列:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

翻译修饰 - P0DMS8 作为底物

Site PTM Type Enzyme
S213 Phosphorylation

研究背景

功能:

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.

细胞定位:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

蛋白家族:

Belongs to the G-protein coupled receptor 1 family.

研究领域

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

文献引用

1). The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain. Animal models and experimental medicine, 2024 (PubMed: 38992885) [IF=3.7]

Application: WB    Species: Mouse    Sample:

FIGURE 2 Multiple electroacupuncture sessions influence the Spinal Adora3 and related enzymes. (A–C) Relative mRNA expression levels of Adora3, CD73, and ADA. (D) Western blot showing protein expression. (E–G) Relative protein expression levels of Adora3, CD73, ADA, and GAPDH. (H) Pearson's correlation analysis of Adora3 and metabolizing enzymes with the nociceptive responses. On days 2EA, 4EA, and 7EA following surgery, samples were obtained from the lumber L4–L6 segments. The data are presented as the means ± SD. Statistical significance was considered at p 

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