| 产品: | EDG4 抗体 |
| 货号: | DF4870 |
| 描述: | Rabbit polyclonal antibody to EDG4 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Sheep |
| 分子量: | 39 KD; 39kD(Calculated). |
| 蛋白号: | Q9HBW0 |
| RRID: | AB_2837233 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4870, RRID:AB_2837233.
展开/折叠
EDG 4; EDG-4; EDG4; Endothelial Cell Differentiation Gene 4; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 4; FLJ93869; G protein coupled receptor; IPA2; LPA 2; LPA receptor 2; LPA receptor EDG4; LPA-2; LPA2; LPAR2; LPAR2_HUMAN; Lysophosphatidic acid receptor 2; Lysophosphatidic acid receptor Edg 4; Lysophosphatidic acid receptor Edg-4; Lysophosphatidic acid receptor EDG4;
抗原和靶标
Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
- Q9HBW0 LPAR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9HBW0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y295 | Phosphorylation | Uniprot | |
| Y325 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| S349 | Phosphorylation | Uniprot | |
| T350 | Phosphorylation | Uniprot |
研究背景
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
Cell surface. Cell membrane>Multi-pass membrane protein.
Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
限制条款
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