产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4892, RRID:AB_2837245.
展开/折叠
G protein coupled receptor 119; G protein coupled receptor 2; G-protein coupled receptor 119; Glucose dependent insulinotropic receptor; Glucose-dependent insulinotropic receptor; GP119_HUMAN; GPCR 2; GPCR2; GPR 119; Gpr119; HGPCR 2; HGPCR2; MGC119957; Seven transmembrane helix receptor;
抗原和靶标
- Q8TDV5 GP119_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8TDV5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K201 | Ubiquitination | Uniprot | |
| T302 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot |
研究背景
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Cell membrane>Multi-pass membrane protein.
Predominantly expressed in the pancreas, especially in the islets.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
限制条款
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