产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4913, RRID:AB_2837266.
展开/折叠
MGC138426; MGC138452; Parathyroid hormone 1 receptor; Parathyroid hormone/parathyroid hormone related peptide receptor; Parathyroid hormone/parathyroid hormone related protein receptor; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH receptor; PTH/PTHr receptor; PTH/PTHrP receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTH1R; PTH1R_HUMAN; PTHR 1; PTHR; PTHR1;
抗原和靶标
- Q03431 PTH1R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q03431 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y23 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| T99 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| T387 | Phosphorylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| Y494 | Phosphorylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| Y496 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| T547 | Phosphorylation | Uniprot | |
| T551 | Phosphorylation | Uniprot | |
| T591 | Phosphorylation | Uniprot |
研究背景
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
N-glycosylated.
Cell membrane>Multi-pass membrane protein.
Expressed in most tissues. Most abundant in kidney, bone and liver.
Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer.
Belongs to the G-protein coupled receptor 2 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
限制条款
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