| 产品: | GPRC6A 抗体 |
| 货号: | DF4964 |
| 描述: | Rabbit polyclonal antibody to GPRC6A |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
| 分子量: | 105 KD; 105kD(Calculated). |
| 蛋白号: | Q5T6X5 |
| RRID: | AB_2837317 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4964, RRID:AB_2837317.
展开/折叠
bA86F4.3; G protein coupled receptor 33; G protein coupled receptor family C group 6 member A; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33; GPC6A_HUMAN; GPCR 33; GPCR 6A; GPCR; GPCR33; GPR C6A; GPRC 6A; gprc6a; hGPCR 33; hGPCR33; hGPRC6A; OTTHUMP00000017075; Predicted with SOSUI analysis; seven transmembrane helix receptor;
抗原和靶标
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.
- Q5T6X5 GPC6A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q5T6X5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T107 | Phosphorylation | Uniprot | |
| N121 | N-Glycosylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| N259 | N-Glycosylation | Uniprot | |
| T261 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| N332 | N-Glycosylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| N378 | N-Glycosylation | Uniprot | |
| N452 | N-Glycosylation | Uniprot | |
| N555 | N-Glycosylation | Uniprot | |
| N567 | N-Glycosylation | Uniprot | |
| T621 | Phosphorylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| Y778 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot |
研究背景
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
N-glycosylated.
Cell membrane>Multi-pass membrane protein.
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.
Homodimer; disulfide-linked.
Belongs to the G-protein coupled receptor 3 family.
研究领域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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