(1)
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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4973, RRID:AB_2837326.
展开/折叠
G protein coupled receptor 35; G protein coupled receptor 35; GPR 35; GPR35; KYNA receptor; Kynurenic acid receptor; Probable G protein coupled receptor 35; Probable G protein coupled receptor GPR35;
抗原和靶标
- Q9HC97 GPR35_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9HC97 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T4 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| Y259 | Phosphorylation | Uniprot | |
| T261 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot |
研究背景
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Cell membrane>Multi-pass membrane protein.
Note: Internalized to the cytoplasm after exposure to kynurenic acid.
Predominantly expressed in immune and gastrointestinal tissues.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
文献引用
Application: IHC Species: human Sample: colon and tumor
限制条款
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