MTLR Antibody - #DF4993

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产品: MTLR 抗体
货号: DF4993
描述: Rabbit polyclonal antibody to MTLR
应用: WB IF/ICC
反应: Human
分子量: 45 KD; 45kD(Calculated).
蛋白号: O43193
RRID: AB_2837352

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
MTLR Antibody detects endogenous levels of total MTLR.
RRID:
AB_2837352
引用格式: Affinity Biosciences Cat# DF4993, RRID:AB_2837352.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

G-protein coupled receptor 38; GPR38; MLNR; Motilin receptor; MTLR; MTLR_HUMAN; MTLR1;

抗原和靶标

免疫原:
Uniprot:

O43193(MTLR_HUMAN) >>Visit HPA database.

基因/基因ID:
MLNR(2862)
表达:
O43193 MTLR_HUMAN:

Expressed only in thyroid, stomach, and bone marrow.

序列:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

翻译修饰 - O43193 作为底物

Site PTM Type Enzyme
T71 Phosphorylation
T72 Phosphorylation
T73 Phosphorylation
S83 Phosphorylation
R136 Methylation
T296 Phosphorylation
T324 Phosphorylation
S327 Phosphorylation
T402 Phosphorylation
T404 Phosphorylation

研究背景

功能:

Receptor for motilin.

细胞定位:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed only in thyroid, stomach, and bone marrow.

蛋白家族:

Belongs to the G-protein coupled receptor 1 family.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

文献引用

1). Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors. Frontiers in Neuroscience, 2023 (PubMed: 36816129) [IF=4.3]

Application: IF/ICC    Species: Rat    Sample: spinal cord

FIGURE 2 (A) Motilin (MTL) and MTL receptor (MTLR) fluorescence co-labeling in the spinal dorsal horn 2 h after acute incisional pain. (B) Co-labeling of MTLR and β-tubulin III fluorescence in the spinal dorsal horn. MTL (red), MTLR (green), β-tubulin III (violet), and DAPI (blue). Scale bar = 100 μm/20 μm.

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