产品: MTR1B 抗体
货号: DF4994
描述: Rabbit polyclonal antibody to MTR1B
应用: WB IF/ICC
反应: Human, Rat
分子量: 40 KD; 40kD(Calculated).
蛋白号: P49286
RRID: AB_2837353

浏览相似产品>>

   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

联系销售

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
克隆:
Polyclonal
特异性:
MTR1B Antibody detects endogenous levels of total MTR1B.
RRID:
AB_2837353
引用格式: Affinity Biosciences Cat# DF4994, RRID:AB_2837353.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FGQTL2; Mel 1b; Mel 1b melatonin receptor; Mel 1B R; MEL-1B-R; Mel1b; Mel1b melatonin receptor; Mel1b receptor; Mel1BR; melatonin receptor 1B; Melatonin receptor MEL 1B; Melatonin receptor MEL1B; Melatonin receptor type 1B; MT 2; MT 2 melatonin receptor; MT2; MT2 melatonin receptor; Mtnr 1b; Mtnr1b; MTR1B_HUMAN;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P49286 MTR1B_HUMAN:

Expressed in retina and less in brain and hippocampus.

序列:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL

研究背景

功能:

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

细胞定位:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in retina and less in brain and hippocampus.

亚基结构:

Interacts with GPR61, GPR62 and GPR135.

蛋白家族:

Belongs to the G-protein coupled receptor 1 family.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Environmental adaptation > Circadian entrainment.

文献引用

1). Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function. JOURNAL OF LIPID RESEARCH, 2019 (PubMed: 30552289) [IF=6.5]

Application: WB    Species: pig    Sample: porcine intramuscular preadipocytes

Fig.?4.|Melatonin receptor (MT2) participates in lipolysis in precursor adipocytes. A: The mRNA levels of MT1 and MT2 mRNA were measured in melatonintreated mature adipocytes by RT-qPCR. B, C: Western blot analyses were performed to detect the changes of MT1 and MT2. D–F: RT-qPCR analysis of genes involved in lipolysis in mature adipocytes cultivated in GM, GM + melatonin, and GM + melatonin + 4-PPDOT medium for 48 h. Data are represented as the mean ± SEM (*P < 0.05; **P < 0.01; ***P < 0.001; n = 3).

限制条款

产品的规格、报价、验证数据请以官网为准,官网链接:www.affbiotech.com | www.affbiotech.cn(简体中文)| www.affbiotech.jp(日本語)

产品的数据信息为Affinity所有,未经授权不得收集Affinity官网数据或资料用于商业用途,对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整,如您已订购该产品,请以订购时随货说明书为准,否则请以官网内容为准,官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时,请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.