| 产品: | OPRD1 抗体 |
| 货号: | DF5043 |
| 描述: | Rabbit polyclonal antibody to OPRD1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Bovine, Rabbit |
| 分子量: | 36 KD; 40kD(Calculated). |
| 蛋白号: | P41143 |
| RRID: | AB_2837402 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF5043, RRID:AB_2837402.
展开/折叠
D-OR-1; Delta type opioid receptor; Delta type opioid receptor DOR 1; Delta type opioid receptor DOR1; Delta-type opioid receptor; DOR 1; DOR-1; DOR1; mDOR; Nbor; Opioid receptor delta 1; OPRD 1; OPRD; OPRD_HUMAN; Oprd1;
抗原和靶标
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
- P41143 OPRD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P41143 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T161 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| T211 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Q05655 (PRKCD) , Q02156 (PRKCE) , P17252 (PRKCA) | Uniprot |
| T358 | Phosphorylation | P25098 (GRK2) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T361 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| S363 | Phosphorylation | P25098 (GRK2) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
研究背景
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
N-glycosylated.
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
Cell membrane>Multi-pass membrane protein.
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1. Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
限制条款
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