| 产品: | PAR4 抗体 |
| 货号: | DF5212 |
| 描述: | Rabbit polyclonal antibody to PAR4 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep |
| 分子量: | 41 KD; 41kD(Calculated). |
| 蛋白号: | Q96RI0 |
| RRID: | AB_2837561 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF5212, RRID:AB_2837561.
展开/折叠
Coagulation factor II (thrombin) receptor like 3; Coagulation factor II receptor like 3; Coagulation factor II receptor-like 3; F2RL3; PAR 4; PAR-4; PAR4; PAR4_HUMAN; protease activated receptor 4; protease activated receptor4; Proteinase activated receptor 4; Proteinase-activated receptor 4; Thrombin receptor like 3; Thrombin receptor-like 3;
抗原和靶标
Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
- Q96RI0 PAR4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96RI0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S366 | Phosphorylation | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot |
研究背景
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Cell membrane>Multi-pass membrane protein.
Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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