Cathepsin G Antibody - #AF5167

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产品: Cathepsin G 抗体
货号: AF5167
描述: Rabbit polyclonal antibody to Cathepsin G
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
分子量: 28 kDa; 29kD(Calculated).
蛋白号: P08311
RRID: AB_2837653

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
Cathepsin G Antibody detects endogenous levels of total Cathepsin G.
RRID:
AB_2837653
引用格式: Affinity Biosciences Cat# AF5167, RRID:AB_2837653.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CATG; CATG_HUMAN; Cathepsin G; Cathepsin G precursor; CathepsinG; CG; Ctsg; CTSG protein; MGC23078;

抗原和靶标

免疫原:
Uniprot:

P08311(CATG_HUMAN) >>Visit HPA database.

基因/基因ID:
CTSG(1511)
描述:
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
序列:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL

翻译修饰 - P08311 作为底物

Site PTM Type Enzyme
S233 Phosphorylation

研究背景

功能:

Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

细胞定位:

Cell surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

(Microbial infection) Interacts with M.tuberculosis protein Rv3364c.

蛋白家族:

Belongs to the peptidase S1 family.

研究领域

· Cellular Processes > Transport and catabolism > Lysosome.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

· Human Diseases > Immune diseases > Systemic lupus erythematosus.

· Organismal Systems > Endocrine system > Renin-angiotensin system.   (View pathway)

文献引用

1). Identification of a novel immune gene panel in tongue squamous cell carcinoma. American Journal of Translational Research, 2022 (PubMed: 35702068) [IF=2.2]

Application: IHC    Species: Human    Sample: tumor

Figure 11 Clinical validation for the predicting efficiency of immune-gene panel. A. Relative expression levels of CTSG, CXCL13 and VEGFA in tongue squamous cell carcinoma samples among different T stages in TCGA dataset. B. Relative expression levels of CTSG, CXCL13 and VEGFA in tongue squamous cell carcinoma samples among different N stages in TCGA dataset. C. Clinical validation of VEGFA, CXCL13 and CTSG expression levels in tumor samples at pathologic T1, T3 and T4 stage with the help of IHC staining images. D. Clinical validation of VEGFA, CXCL13, and CTSG expression levels in tumor samples at pathological N0 and N2 stages with the help of IHC staining images. E-G. Clinical validation for accumulation of Th17 cells, CD4+ T cells and CD8+ T cells in TSCC by immunofluorescent staining.

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