产品: INSL3 抗体
货号: AF5227
描述: Rabbit polyclonal antibody to INSL3
应用: WB
反应: Human
预测: Pig, Dog
分子量: 14 kDa; 15kD(Calculated).
蛋白号: P51460
RRID: AB_2837713

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(88%), Dog(88%)
克隆:
Polyclonal
特异性:
INSL3 Antibody detects endogenous levels of total INSL3.
RRID:
AB_2837713
引用格式: Affinity Biosciences Cat# AF5227, RRID:AB_2837713.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

INSL 3; INSL3; INSL3_HUMAN; Insulin like 3; insulin like peptide, Leydig cell-specific; insulin-like 3 (Leydig cell); Insulin-like 3 A chain; Ley IL; Ley-I-L; leydig insulin -like hormone; Leydig insulin like peptide; Leydig insulin-like peptide; prepro-INSL3; Relaxin like factor; Relaxin-like factor; relaxin-like factor b; RLF; RLNL;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P51460 INSL3_HUMAN:

Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.

描述:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Heterodimer of a B chain and an A chain linked by two disulfide bonds
序列:
MDPRLPAWALVLLGPALVFALGPAPTPEMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
88
Dog
88
Bovine
71
Horse
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

功能:

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.

亚基结构:

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

蛋白家族:

Belongs to the insulin family.

研究领域

· Organismal Systems > Endocrine system > Relaxin signaling pathway.

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