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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF5237, RRID:AB_2837723.
展开/折叠
FLJ25596; Guanine nucleotide exchange factor; Guanine nucleotide releasing factor; Son of sevenless (Drosophilia) homolog 2; Son of sevenless homolog 2 (Drosophila); Son of sevenless homolog 2; SOS 2; SOS-2; Sos2; SOS2_HUMAN;
抗原和靶标
- Q07890 SOS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q07890 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K76 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| Y346 | Phosphorylation | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| Y389 | Phosphorylation | Uniprot | |
| Y392 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K470 | Acetylation | Uniprot | |
| K527 | Ubiquitination | Uniprot | |
| K578 | Ubiquitination | Uniprot | |
| Y613 | Phosphorylation | Uniprot | |
| Y616 | Phosphorylation | Uniprot | |
| K658 | Acetylation | Uniprot | |
| K663 | Ubiquitination | Uniprot | |
| Y679 | Phosphorylation | Uniprot | |
| S791 | Phosphorylation | Uniprot | |
| Y794 | Phosphorylation | Uniprot | |
| S800 | Phosphorylation | Uniprot | |
| K809 | Ubiquitination | Uniprot | |
| R846 | Methylation | Uniprot | |
| R852 | Methylation | Uniprot | |
| K949 | Methylation | Uniprot | |
| K949 | Ubiquitination | Uniprot | |
| K958 | Methylation | Uniprot | |
| K958 | Ubiquitination | Uniprot | |
| Y1006 | Phosphorylation | Uniprot | |
| K1010 | Ubiquitination | Uniprot | |
| T1030 | Phosphorylation | Uniprot | |
| S1032 | Phosphorylation | Uniprot | |
| S1035 | Phosphorylation | Uniprot | |
| S1047 | Phosphorylation | Uniprot | |
| T1048 | Phosphorylation | Uniprot | |
| T1051 | Phosphorylation | Uniprot | |
| T1057 | Phosphorylation | Uniprot | |
| S1128 | Phosphorylation | Uniprot | |
| S1132 | Phosphorylation | Uniprot | |
| S1135 | Phosphorylation | Uniprot | |
| S1168 | Phosphorylation | Uniprot | |
| S1202 | Phosphorylation | Uniprot | |
| S1258 | Phosphorylation | Uniprot | |
| S1260 | Phosphorylation | Uniprot | |
| T1261 | Phosphorylation | Uniprot | |
| S1267 | Phosphorylation | Uniprot | |
| Y1275 | Phosphorylation | Uniprot | |
| S1315 | Phosphorylation | Uniprot | |
| Y1320 | Phosphorylation | Uniprot |
研究背景
Promotes the exchange of Ras-bound GDP by GTP.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Substance dependence > Alcoholism.
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Human Diseases > Cancers: Specific types > Colorectal cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Renal cell carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Endometrial cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Glioma. (View pathway)
· Human Diseases > Cancers: Specific types > Prostate cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Non-small cell lung cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Breast cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc epsilon RI signaling pathway. (View pathway)
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Prolactin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Relaxin signaling pathway.
文献引用
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