hnRNP M Antibody - #AF5276

(2)  
产品: hnRNP M 抗体
货号: AF5276
描述: Rabbit polyclonal antibody to hnRNP M
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Dog
分子量: 78 kDa; 78kD(Calculated).
蛋白号: P52272
RRID: AB_2837762

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
克隆:
Polyclonal
特异性:
hnRNP M Antibody detects endogenous levels of total hnRNP M.
RRID:
AB_2837762
引用格式: Affinity Biosciences Cat# AF5276, RRID:AB_2837762.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CEA receptor; CEAR; Heterogeneous nuclear ribonucleoprotein M; Heterogenous nuclear ribonucleoprotein M4; hnRNA binding protein M4; hnRNP M; Hnrnpm; HNRNPM4; HNRPM; HNRPM_HUMAN; HNRPM4; HTGR1; M3; M4; M4 protein; N-acetylglucosamine receptor 1; NAGR1;

抗原和靶标

免疫原:
Uniprot:

P52272(HNRPM_HUMAN) >>Visit HPA database.

基因/基因ID:
HNRNPM(4670)
描述:
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
序列:
MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
73
Xenopus
70
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P52272 作为底物

Site PTM Type Enzyme
A2 Acetylation
T14 Phosphorylation
K17 Sumoylation
S22 Phosphorylation
S29 Phosphorylation
K37 Sumoylation
K37 Ubiquitination
K48 Acetylation
K48 Ubiquitination
K52 Methylation
K55 Sumoylation
R56 Methylation
Y64 Phosphorylation
T68 Phosphorylation
K69 Acetylation
K69 Ubiquitination
T76 Phosphorylation
K83 Acetylation
K83 Sumoylation
K83 Ubiquitination
S86 Phosphorylation
K88 Sumoylation
K88 Ubiquitination
K92 Ubiquitination
K94 Ubiquitination
T99 Phosphorylation
Y100 Phosphorylation
K110 Acetylation
K110 Sumoylation
K110 Ubiquitination
C114 S-Nitrosylation
K120 Sumoylation
K120 Ubiquitination
K126 Sumoylation
K126 Ubiquitination
K127 Sumoylation
K127 Ubiquitination
K134 Acetylation
K134 Sumoylation
K134 Ubiquitination
S136 Phosphorylation
S138 Phosphorylation
K143 Sumoylation
K143 Ubiquitination
K145 Sumoylation
K145 Ubiquitination
S204 Phosphorylation
T205 Phosphorylation
Y213 Phosphorylation
K214 Acetylation
K214 Ubiquitination
K218 Ubiquitination
K221 Sumoylation
K221 Ubiquitination
K239 Acetylation
K239 Sumoylation
K239 Ubiquitination
K242 Sumoylation
K242 Ubiquitination
K277 Acetylation
K277 Sumoylation
K277 Ubiquitination
K285 Ubiquitination
K322 Sumoylation
K322 Ubiquitination
K345 Ubiquitination
S365 Phosphorylation
R371 Methylation
S377 Phosphorylation
K381 Acetylation
K381 Sumoylation
K381 Ubiquitination
K388 Sumoylation
K388 Ubiquitination
S397 Phosphorylation
R410 Methylation
R429 Methylation
S432 Phosphorylation O14757 (CHEK1)
R443 Methylation
S446 Phosphorylation
S452 Phosphorylation
S467 Phosphorylation
S468 Phosphorylation
T475 Phosphorylation
S481 Phosphorylation
R485 Methylation
R496 Methylation
R503 Methylation
T507 Phosphorylation
S513 Phosphorylation
S528 Phosphorylation
R543 Methylation
R550 Methylation
R565 Methylation
S575 Phosphorylation
S588 Phosphorylation
S618 Phosphorylation
R621 Methylation
R627 Methylation
S633 Phosphorylation
S637 Phosphorylation
K651 Sumoylation
K651 Ubiquitination
T665 Phosphorylation
K667 Acetylation
K667 Sumoylation
K667 Ubiquitination
K670 Ubiquitination
K672 Acetylation
K672 Sumoylation
K672 Ubiquitination
C676 S-Nitrosylation
Y681 Phosphorylation
K685 Acetylation
K685 Sumoylation
K685 Ubiquitination
K690 Ubiquitination
K692 Ubiquitination
C694 S-Nitrosylation
K698 Acetylation
K698 Sumoylation
K698 Ubiquitination
S701 Phosphorylation
C709 S-Nitrosylation
K716 Sumoylation
K716 Ubiquitination

研究背景

功能:

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

翻译修饰:

Sumoylated.

细胞定位:

Nucleus>Nucleolus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Identified in the spliceosome C complex.

研究领域

· Genetic Information Processing > Transcription > Spliceosome.

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