Cleaved-Notch2 (Asp1733) Antibody - #AF5296

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产品: Cleaved-Notch2 (Asp1733) 抗体
货号: AF5296
描述: Rabbit polyclonal antibody to Cleaved-Notch2 (Asp1733)
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken
蛋白号: Q04721
RRID: AB_2837781

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Cleaved-Notch2 (Asp1733) Antibody detects endogenous levels of fragment of activated Notch2 resulting from cleavage adjacent to Asp1733.
RRID:
AB_2837781
引用格式: Affinity Biosciences Cat# AF5296, RRID:AB_2837781.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AGS2; hN2; Notch homolog 2; Notch2;

抗原和靶标

免疫原:

A synthesized peptide derived from human Notch2 (Cleaved-Asp1733).

基因/基因ID:
NOTCH2(4853)
描述:
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC)

研究领域

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

· Organismal Systems > Immune system > Th1 and Th2 cell differentiation.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

文献引用

1). Notch signaling inhibition induces G0/G1 arrest in murine Leydig cells. Andrologia, 2019 (PubMed: 31523838) [IF=2.1]

Application: IHC    Species: mouse    Sample: interstitial Leydig cells

FIGURE 2|Immunohistochemical (IHC) analysis of Notch receptors and ligands in interstitial Leydig cells of testis slides. Positive immunostaining in brown and counterstaining with haematoxylin (400× magnification). The control was performed with rabbit IgG (a). Expression of Dll‐1, Notch1, Notch2 and Notch3 is shown in interstitial Leydig cells of testis slides (b–e)

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