(1)
(7)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF5397, RRID:AB_2837882.
展开/折叠
B-36 vdac; FLJ23841; hVDAC2; OTTHUMP00000019878; OTTHUMP00000019879; OTTHUMP00000019880; Outer mitochondrial membrane protein porin 2; POR; Porin-2; VDAC 2; VDAC-2; VDAC2; VDAC2_HUMAN; Vdac6; Voltage dependent anion channel 2; Voltage dependent anion selective channel protein 2; Voltage-dependent anion-selective channel protein 2;
抗原和靶标
- P45880 VDAC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P45880 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Ubiquitination | Uniprot | ||
| A2 | Acetylation | Uniprot | |
| T7 | Phosphorylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| K31 | Acetylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K39 | Acetylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| C47 | S-Nitrosylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| T54 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K64 | Sumoylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| T66 | Phosphorylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| K72 | Acetylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| Y73 | Phosphorylation | Uniprot | |
| K74 | Acetylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| C76 | S-Nitrosylation | Uniprot | |
| Y78 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| T112 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| K120 | Acetylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| K172 | Sumoylation | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| K235 | Acetylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| T261 | Phosphorylation | Uniprot | |
| K277 | Acetylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot |
研究背景
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Mitochondrion outer membrane.
Expressed in all tissues examined.
Interacts with hexokinases.
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
Belongs to the eukaryotic mitochondrial porin family.
研究领域
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Digestive system > Cholesterol metabolism.
文献引用
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