产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF5482, RRID:AB_2837963.
展开/折叠
CK 16; CK-16; CK16; Cytokeratin-16; Cytokeratin16; FNEPPK; Focal non epidermolytic palmoplantar keratoderma; K 16; K16; K1C16_HUMAN; K1CP; Keratin 1 type I; Keratin 16; Keratin; Keratin type I cytoskeletal 16; Keratin-16; Keratin16; KRT 16; Krt16; KRT16A; NEPPK; PC1; type I cytoskeletal 16;
抗原和靶标
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
- P08779 K1C16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08779 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| K15 | Methylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| T45 | Phosphorylation | Uniprot | |
| Y46 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| K162 | Acetylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| Y167 | Phosphorylation | Uniprot | |
| K169 | Acetylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| T215 | Phosphorylation | Uniprot | |
| T235 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| T416 | Phosphorylation | Uniprot | |
| Y417 | Phosphorylation | Uniprot | |
| Y438 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| K460 | Methylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot |
研究背景
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TCHP. Interacts with TRADD (By similarity).
Belongs to the intermediate filament family.
研究领域
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
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