| 产品: | BVES 抗体 |
| 货号: | DF6019 |
| 描述: | Rabbit polyclonal antibody to BVES |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 41kDa; 41kD(Calculated). |
| 蛋白号: | Q8NE79 |
| RRID: | AB_2837994 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6019, RRID:AB_2837994.
展开/折叠
Blood vessel epicardial substance; Bves; hBVES; MGC42413; POP 1; POP1; POPD1_HUMAN; POPDC 1; POPDC1; Popeye domain containing 1; Popeye domain containing protein 1; Popeye domain-containing protein 1; Popeye protein 1;
抗原和靶标
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
- Q8NE79 POPD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8NE79 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y3 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K122 | Acetylation | Uniprot | |
| Y194 | Phosphorylation | Uniprot |
研究背景
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.
Lateral cell membrane. Cell junction>Tight junction. Membrane>Multi-pass membrane protein. Cell membrane>Sarcolemma. Membrane>Caveola.
Note: Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells.
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
Homodimer. Homodimerization requires the C-terminus cytoplasmic region. Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3 (By similarity). Interacts with KCNK2; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (By similarity). Interacts with CAV3 (By similarity).
Belongs to the popeye family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
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