产品: | FASN 抗体 |
货号: | DF6106 |
描述: | Rabbit polyclonal antibody to FASN |
应用: | WB IHC |
反应: | Human, Mouse, Rat |
预测: | Zebrafish, Bovine, Horse, Dog |
分子量: | 272kDa; 273kD(Calculated). |
蛋白号: | P49327 |
RRID: | AB_2811172 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6106, RRID:AB_2811172.
展开/折叠
[Acyl-carrier-protein] S acetyltransferase; [Acyl-carrier-protein] S malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; FAS; FAS_HUMAN; FASN; Fatty acid synthase; MGC14367; MGC15706; OA 519; Oleoyl-[acyl-carrier-protein] hydrolase; SDR27X1; Short chain dehydrogenase/reductase family 27X member 1;
抗原和靶标
- P49327 FAS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49327 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
M1 | Acetylation | Uniprot | |
K12 | Sumoylation | Uniprot | |
T34 | Phosphorylation | Uniprot | |
K41 | Ubiquitination | Uniprot | |
Y45 | Phosphorylation | Uniprot | |
S63 | Phosphorylation | Uniprot | |
K70 | Acetylation | Uniprot | |
K70 | Ubiquitination | Uniprot | |
S207 | Phosphorylation | Uniprot | |
T211 | Phosphorylation | Uniprot | |
C212 | S-Nitrosylation | Uniprot | |
K213 | Acetylation | Uniprot | |
K213 | Ubiquitination | Uniprot | |
T217 | Phosphorylation | Uniprot | |
Y222 | Phosphorylation | Uniprot | |
S225 | Phosphorylation | Uniprot | |
K235 | Acetylation | Uniprot | |
K235 | Ubiquitination | Uniprot | |
T245 | Phosphorylation | Uniprot | |
T251 | Phosphorylation | Uniprot | |
T253 | Phosphorylation | Uniprot | |
K257 | Acetylation | Uniprot | |
K257 | Ubiquitination | Uniprot | |
S265 | Phosphorylation | Uniprot | |
Y277 | Phosphorylation | Uniprot | |
S279 | Phosphorylation | Uniprot | |
S286 | Phosphorylation | Uniprot | |
Y289 | Phosphorylation | Uniprot | |
K298 | Acetylation | Uniprot | |
K298 | Ubiquitination | Uniprot | |
K326 | Ubiquitination | Uniprot | |
S361 | Phosphorylation | Uniprot | |
K436 | Acetylation | Uniprot | |
K436 | Ubiquitination | Uniprot | |
T463 | Phosphorylation | Uniprot | |
Y470 | Phosphorylation | Uniprot | |
S509 | Phosphorylation | Uniprot | |
K528 | Acetylation | Uniprot | |
K528 | Ubiquitination | Uniprot | |
K611 | Ubiquitination | Uniprot | |
K631 | Acetylation | Uniprot | |
K631 | Ubiquitination | Uniprot | |
C634 | S-Nitrosylation | Uniprot | |
C642 | S-Nitrosylation | Uniprot | |
K646 | Acetylation | Uniprot | |
K646 | Ubiquitination | Uniprot | |
K667 | Ubiquitination | Uniprot | |
K673 | Acetylation | Uniprot | |
K673 | Ubiquitination | Uniprot | |
S724 | Phosphorylation | Uniprot | |
S725 | Phosphorylation | Uniprot | |
K772 | Ubiquitination | Uniprot | |
K776 | Acetylation | Uniprot | |
K776 | Ubiquitination | Uniprot | |
K786 | Acetylation | Uniprot | |
K787 | Acetylation | Uniprot | |
K787 | Ubiquitination | Uniprot | |
T827 | Phosphorylation | Uniprot | |
S831 | Phosphorylation | Uniprot | |
K897 | Ubiquitination | Uniprot | |
T898 | Phosphorylation | Uniprot | |
K927 | Ubiquitination | Uniprot | |
T928 | Phosphorylation | Uniprot | |
T930 | Phosphorylation | Uniprot | |
S974 | Phosphorylation | Uniprot | |
T976 | Phosphorylation | Uniprot | |
T980 | Phosphorylation | Uniprot | |
K992 | Acetylation | Uniprot | |
K992 | Ubiquitination | Uniprot | |
S1028 | Phosphorylation | Uniprot | |
T1032 | Phosphorylation | Uniprot | |
Y1047 | Phosphorylation | Uniprot | |
K1065 | Ubiquitination | Uniprot | |
Y1067 | Phosphorylation | Uniprot | |
K1072 | Acetylation | Uniprot | |
K1072 | Ubiquitination | Uniprot | |
S1081 | Phosphorylation | Uniprot | |
K1116 | Acetylation | Uniprot | |
K1116 | Ubiquitination | Uniprot | |
C1118 | S-Nitrosylation | Uniprot | |
T1120 | Phosphorylation | Uniprot | |
C1127 | S-Nitrosylation | Uniprot | |
K1142 | Ubiquitination | Uniprot | |
K1151 | Acetylation | Uniprot | |
K1151 | Ubiquitination | Uniprot | |
K1158 | Ubiquitination | Uniprot | |
S1174 | Phosphorylation | Uniprot | |
S1183 | Phosphorylation | Uniprot | |
K1208 | Ubiquitination | Uniprot | |
S1216 | Phosphorylation | Uniprot | |
S1221 | Phosphorylation | Uniprot | |
K1225 | Ubiquitination | Uniprot | |
S1237 | Phosphorylation | Uniprot | |
K1239 | Acetylation | Uniprot | |
K1239 | Ubiquitination | Uniprot | |
K1241 | Ubiquitination | Uniprot | |
S1254 | Phosphorylation | Uniprot | |
S1261 | Phosphorylation | Uniprot | |
T1273 | Phosphorylation | Uniprot | |
Y1367 | Phosphorylation | Uniprot | |
S1373 | Phosphorylation | Uniprot | |
S1379 | Phosphorylation | Uniprot | |
S1382 | Phosphorylation | Uniprot | |
K1393 | Ubiquitination | Uniprot | |
T1407 | Phosphorylation | Uniprot | |
S1411 | Phosphorylation | Uniprot | |
S1421 | Phosphorylation | Uniprot | |
K1429 | Acetylation | Uniprot | |
K1429 | Ubiquitination | Uniprot | |
K1444 | Ubiquitination | Uniprot | |
C1471 | S-Nitrosylation | Uniprot | |
S1479 | Phosphorylation | Uniprot | |
Y1506 | Phosphorylation | Uniprot | |
K1523 | Acetylation | Uniprot | |
K1523 | Ubiquitination | Uniprot | |
S1542 | Phosphorylation | Uniprot | |
S1543 | Phosphorylation | Uniprot | |
R1552 | Methylation | Uniprot | |
K1582 | Acetylation | Uniprot | |
K1582 | Ubiquitination | Uniprot | |
S1584 | Phosphorylation | Uniprot | |
K1591 | Acetylation | Uniprot | |
K1591 | Ubiquitination | Uniprot | |
T1593 | Phosphorylation | Uniprot | |
S1594 | Phosphorylation | Uniprot | |
S1597 | Phosphorylation | Uniprot | |
S1701 | Phosphorylation | Uniprot | |
K1704 | Acetylation | Uniprot | |
K1704 | Ubiquitination | Uniprot | |
S1723 | Phosphorylation | Uniprot | |
K1739 | Ubiquitination | Uniprot | |
S1747 | Phosphorylation | Uniprot | |
K1752 | Acetylation | Uniprot | |
K1752 | Ubiquitination | Uniprot | |
K1771 | Acetylation | Uniprot | |
K1827 | Ubiquitination | Uniprot | |
K1847 | Acetylation | Uniprot | |
K1847 | Ubiquitination | Uniprot | |
K1851 | Ubiquitination | Uniprot | |
K1866 | Ubiquitination | Uniprot | |
K1869 | Ubiquitination | Uniprot | |
K1871 | Ubiquitination | Uniprot | |
S1874 | Phosphorylation | Uniprot | |
S1877 | Phosphorylation | Uniprot | |
K1878 | Acetylation | Uniprot | |
K1878 | Ubiquitination | Uniprot | |
K1911 | Ubiquitination | Uniprot | |
K1927 | Acetylation | Uniprot | |
K1927 | Ubiquitination | Uniprot | |
S1947 | Phosphorylation | Uniprot | |
S1948 | Phosphorylation | Uniprot | |
K1993 | Acetylation | Uniprot | |
K1993 | Ubiquitination | Uniprot | |
K1995 | Acetylation | Uniprot | |
K1995 | Ubiquitination | Uniprot | |
S1997 | Phosphorylation | Uniprot | |
T1999 | Phosphorylation | Uniprot | |
R2004 | Methylation | Uniprot | |
Y2034 | Phosphorylation | Uniprot | |
R2043 | Methylation | Uniprot | |
K2047 | Ubiquitination | Uniprot | |
S2123 | Phosphorylation | Uniprot | |
S2156 | Phosphorylation | Uniprot | |
S2175 | Phosphorylation | Uniprot | |
K2186 | Ubiquitination | Uniprot | |
S2192 | Phosphorylation | Uniprot | |
K2193 | Ubiquitination | Uniprot | |
S2198 | Phosphorylation | Uniprot | |
C2202 | S-Nitrosylation | Uniprot | |
T2204 | Phosphorylation | Uniprot | |
K2206 | Acetylation | Uniprot | |
T2215 | Phosphorylation | Uniprot | |
S2236 | Phosphorylation | Uniprot | |
S2265 | Phosphorylation | Uniprot | |
T2268 | Phosphorylation | Uniprot | |
Y2269 | Phosphorylation | Uniprot | |
T2356 | Phosphorylation | Uniprot | |
K2391 | Acetylation | Uniprot | |
K2391 | Ubiquitination | Uniprot | |
K2406 | Ubiquitination | Uniprot | |
R2413 | Methylation | Uniprot | |
S2417 | Phosphorylation | Uniprot | |
Y2424 | Phosphorylation | Uniprot | |
Y2425 | Phosphorylation | Uniprot | |
K2426 | Acetylation | Uniprot | |
K2426 | Ubiquitination | Uniprot | |
R2428 | Methylation | Uniprot | |
Y2433 | Phosphorylation | Uniprot | |
T2434 | Phosphorylation | Uniprot | |
K2436 | Acetylation | Uniprot | |
K2436 | Ubiquitination | Uniprot | |
K2438 | Acetylation | Uniprot | |
K2438 | Ubiquitination | Uniprot | |
K2449 | Sumoylation | Uniprot | |
K2449 | Ubiquitination | Uniprot | |
K2471 | Acetylation | Uniprot | |
K2471 | Ubiquitination | Uniprot | |
T2483 | Phosphorylation | Uniprot | |
S2488 | Phosphorylation | Uniprot | |
S2499 | Phosphorylation | Uniprot | |
S2507 | Phosphorylation | Uniprot |
研究背景
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
Cytoplasm. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Ubiquitous. Prominent expression in brain, lung, and liver.
Homodimer which is arranged in a head to tail fashion Ref.28). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity).
研究领域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
文献引用
Application: WB Species: Rat Sample: hepatic tissue
Application: WB Species: Mouse Sample: livers
Application: IHC Species: Mouse Sample:
Application: WB Species: Human Sample: SK-HEP-1 cells
Application: WB Species: mouse Sample: liver
Application: WB Species: bovine Sample: bovine cells
Application: WB Species: Human Sample: adipose tissue
Application: WB Species: Human Sample: L-02 cells
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