SGK1 Antibody - #DF6188

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产品: SGK1 抗体
货号: DF6188
描述: Rabbit polyclonal antibody to SGK1
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken
蛋白号: O00141
RRID: AB_2838154

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SGK1 Antibody detects endogenous levels of total SGK1.
RRID:
AB_2838154
引用格式: Affinity Biosciences Cat# DF6188, RRID:AB_2838154.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

OTTHUMP00000017247; Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serine/threonine-protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid regulated kinase; Serum/glucocorticoid-regulated kinase 1; SGK 1; SGK; SGK1; Sgk1 variant i3; SGK1_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human SGK1, corresponding to a region within the internal amino acids.

基因/基因ID:
SGK1(6446)
描述:
Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt (1). SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways (2,3). Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation (4-6). SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion (2). SGK is negatively regulated by ubiquitination and proteasome degradation (7). The MAP kinase family member BMK1 interacts with and activates SGK by phosphorylation at serine 78 (6).

研究领域

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > mTOR signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.

文献引用

1). Glucocorticoids ameliorate cardiorenal syndrome through the NPR1/SGK1 pathway in natriuretic peptide receptor A‑heterozygous mice. Experimental and Therapeutic Medicine, 2023 (PubMed: 37415837) [IF=2.4]

Application: WB    Species: Mouse    Sample: heart tissue

Figure 5 NPR1 and SGK1 expression levels. (A) Analysis of NPR1 and SGK1 expression levels in the heart tissue of WT, Npr1+/-, WT + DEX and Npr1+/- + DEX mice (n=4/group) using immunofluorescence (magnification, x100; scale bar, 100 µm). (B) Analysis of NPR1 and SGK1 expression levels in the heart tissues of WT, Npr1+/-, WT + DEX and DEX + Npr1+/- mice using western blotting. (C) Relative expression of SGK1 using western blotting. (D) Relative expression levels of NPR1 using western blotting. *P

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