| 产品: | RHOC 抗体 |
| 货号: | DF6207 |
| 描述: | Rabbit polyclonal antibody to RHOC |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Dog, Chicken |
| 分子量: | 22kDa; 22kD(Calculated). |
| 蛋白号: | P08134 |
| RRID: | AB_2838173 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6207, RRID:AB_2838173.
展开/折叠
ARH12; ARHA; H12; ras homolog gene family member A; ras homolog gene family member B; ras homolog gene family member C; Rho cDNA clone 12; RHO12; RHOA; RHOA_HUMAN; rhob; rhoc; RHOH12; Small GTP binding protein RhoA; Transforming protein RhoA;
抗原和靶标
- P08134 RHOC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08134 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K7 | Ubiquitination | Uniprot | |
| T19 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K27 | Sumoylation | Uniprot | |
| Y34 | Phosphorylation | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| Y66 | Phosphorylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| C107 | S-Nitrosylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| K119 | Methylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| Y156 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot |
研究背景
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
Cell membrane>Lipid-anchor>Cytoplasmic side. Cleavage furrow.
Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
Interacts with RTKN (By similarity). Interacts with AKAP13. Interacts with DIAPH1. Interacts with PKN2. Interacts with ROCK1 and ROCK2. Interacts with ARHGDIA. Interacts with RIPOR1.
Belongs to the small GTPase superfamily. Rho family.
限制条款
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