产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6215, RRID:AB_2838181.
展开/折叠
Actin binding protein (Schizosaccharomyces pombe sop2 like); Actin related protein 2/3 complex subunit 1A 41kDa; Actin-related protein 2/3 complex subunit 1A; ARC1A_HUMAN; Arc40; ARPC1A; Epididymis luminal protein 68; Epididymis secretory protein Li 307; HEL 68; HEL S 307; SOP2-like protein; SOP2Hs; SOP2L;
抗原和靶标
- Q92747 ARC1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92747 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| R74 | Methylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K174 | Acetylation | Uniprot | |
| K179 | Acetylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| K358 | Ubiquitination | Uniprot |
研究背景
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Cytoplasm>Cytoskeleton. Nucleus.
Probable component of the Arp2/3 complex in which it may replace ARPC1B (Probable). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).
Belongs to the WD repeat ARPC1 family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.
· Human Diseases > Infectious diseases: Bacterial > Shigellosis.
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
限制条款
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