产品: GPX5 抗体
货号: DF6220
描述: Rabbit polyclonal antibody to GPX5
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 25kDa; 25kD(Calculated).
蛋白号: O75715
RRID: AB_2838186

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(82%), Bovine(90%), Horse(90%), Sheep(90%), Rabbit(90%), Dog(80%)
克隆:
Polyclonal
特异性:
GPX5 Antibody detects endogenous levels of total GPX5.
RRID:
AB_2838186
引用格式: Affinity Biosciences Cat# DF6220, RRID:AB_2838186.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Arep; arMEP24; EGLP; Epididymal androgen related protein; Epididymal secretory glutathione peroxidase; epididymis secretory sperm binding protein Li 75p; Epididymis specific glutathione peroxidase like protein; Epididymis-specific glutathione peroxidase-like protein; Glutathione peroxidase 5 (epididymal androgen related protein); Glutathione peroxidase 5; Glutathione peroxidase, epididymal; GPx-5; GPX5; GPX5_HUMAN; GSHPx-5; HEL-S-75p; Major androgen regulated protein; OTTHUMP00000017919; OTTHUMP00000214636;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
O75715 GPX5_HUMAN:

Epididymis.

描述:
GPX5 belongs to the glutathione peroxidase family. GPX5 protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Catalytic the reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O. GPX5 constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids.
序列:
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLKYVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Horse
90
Bovine
90
Sheep
90
Rabbit
90
Pig
82
Dog
80
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - O75715 作为底物

Site PTM Type Enzyme
Y41 Phosphorylation
K167 Methylation

研究背景

功能:

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Epididymis.

蛋白家族:

Belongs to the glutathione peroxidase family.

研究领域

· Metabolism > Metabolism of other amino acids > Glutathione metabolism.

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

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