产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6221, RRID:AB_2838187.
展开/折叠
3 hydroxyacyl Coenzyme A dehydrogenase; HAD; HADH; HADH1; HADHSC; HADHSC, formerly; HADSC, formerly; HCDH; HCDH_HUMAN; HHF4; Hydroxyacyl CoA dehydrogenase; Hydroxyacyl-coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; L 3 hydroxyacyl Coenzyme A dehydrogenase short chain; M SCHAD; Medium and short chain L 3 hydroxyacyl coenzyme A dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; MGC8392; mitochondrial; MSCHAD; OTTHUMP00000162626; OTTHUMP00000219688; SCHAD; SCHAD, formerly; Short chain 3 hydroxyacyl CoA dehydrogenase mitochondrial; short chain 3-hydroxyacyl-coa dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase;
抗原和靶标
- Q16836 HCDH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q16836 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S13 | Phosphorylation | Uniprot | |
K68 | Ubiquitination | Uniprot | |
S73 | Phosphorylation | Uniprot | |
R75 | Methylation | Uniprot | |
K76 | Acetylation | Uniprot | |
K80 | Acetylation | Uniprot | |
K81 | Acetylation | Uniprot | |
K87 | Acetylation | Uniprot | |
K87 | Ubiquitination | Uniprot | |
K127 | Ubiquitination | Uniprot | |
K132 | Acetylation | Uniprot | |
K179 | Acetylation | Uniprot | |
K185 | Acetylation | Uniprot | |
K185 | Ubiquitination | Uniprot | |
K192 | Acetylation | Uniprot | |
K192 | Ubiquitination | Uniprot | |
T193 | Phosphorylation | Uniprot | |
S196 | Phosphorylation | Uniprot | |
S201 | Phosphorylation | Uniprot | |
K202 | Acetylation | Uniprot | |
K202 | Ubiquitination | Uniprot | |
K206 | Ubiquitination | Uniprot | |
K212 | Acetylation | Uniprot | |
K212 | Ubiquitination | Uniprot | |
T214 | Phosphorylation | Uniprot | |
Y226 | Phosphorylation | Uniprot | |
Y234 | Phosphorylation | Uniprot | |
K241 | Acetylation | Uniprot | |
K241 | Ubiquitination | Uniprot | |
K249 | Acetylation | Uniprot | |
Y264 | Phosphorylation | Uniprot | |
T269 | Phosphorylation | Uniprot | |
T270 | Phosphorylation | Uniprot | |
S290 | Phosphorylation | Uniprot | |
K301 | Ubiquitination | Uniprot | |
K304 | Acetylation | Uniprot | |
K312 | Acetylation | Uniprot | |
K312 | Methylation | Uniprot | |
K312 | Ubiquitination | Uniprot | |
Y313 | Phosphorylation | Uniprot |
研究背景
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).
Mitochondrion matrix.
Expressed in liver, kidney, pancreas, heart and skeletal muscle.
Homodimer.
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
研究领域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Lysine degradation.
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Carbohydrate metabolism > Butanoate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
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