| 产品: | MAGED1 抗体 |
| 货号: | DF6235 |
| 描述: | Rabbit polyclonal antibody to MAGED1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 86kDa; 86kD(Calculated). |
| 蛋白号: | Q9Y5V3 |
| RRID: | AB_2838201 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6235, RRID:AB_2838201.
展开/折叠
DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged1; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin receptor interacting MAGE homolog; Neurotrophin receptor-interacting MAGE homolog; NRAGE; PP2250;
抗原和靶标
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
- Q9Y5V3 MAGD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y5V3 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S76 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| Y92 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| K109 | Acetylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| Y126 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K147 | Methylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| T179 | Phosphorylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Uniprot | |
| T316 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| K529 | Ubiquitination | Uniprot | |
| K555 | Ubiquitination | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| R604 | Methylation | Uniprot | |
| K605 | Ubiquitination | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| Y630 | Phosphorylation | Uniprot | |
| S638 | Phosphorylation | Uniprot | |
| T642 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| K644 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot |
研究背景
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Cytoplasm. Cell membrane>Peripheral membrane protein. Nucleus.
Note: Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
研究领域
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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