产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6278, RRID:AB_2838244.
展开/折叠
Apoferritin; Cell proliferation inducing gene 15 protein; Cell proliferation-inducing gene 15 protein; F HC; Ferritin H subunit; Ferritin heavy chain; Ferritin heavy polypeptide 1; FHC; FRIH; FRIH_HUMAN; FTH 1; FTH; FTH1; FTH1 protein; FTHL 6; FTHL6; Iron overload autosomal dominant; MGC104426; N-terminally processed; OK/SW-cl.84; PIG 15; PIG15; Placenta immunoregulatory factor; PLIF; Proliferation inducing gene 15 protein; Proliferation inducing protein 15;
抗原和靶标
- P02794 FRIH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P02794 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
M1 | Acetylation | Uniprot | |
T2 | Acetylation | Uniprot | |
T6 | Phosphorylation | Uniprot | |
S7 | Phosphorylation | Uniprot | |
Y13 | Phosphorylation | Uniprot | |
K54 | Ubiquitination | Uniprot | |
K69 | Ubiquitination | Uniprot | |
K72 | Sumoylation | Uniprot | |
K72 | Ubiquitination | Uniprot | |
K88 | Ubiquitination | Uniprot | |
S96 | Phosphorylation | Uniprot | |
K109 | Ubiquitination | Uniprot | |
S114 | Phosphorylation | Uniprot | |
K120 | Ubiquitination | Uniprot | |
K125 | Ubiquitination | Uniprot | |
K144 | Ubiquitination | Uniprot | |
K147 | Ubiquitination | Uniprot | |
K158 | Ubiquitination | Uniprot | |
S164 | Phosphorylation | Uniprot | |
Y169 | Phosphorylation | Uniprot | |
T175 | Phosphorylation | Uniprot | |
S179 | Phosphorylation | Uniprot | |
S183 | Phosphorylation | Uniprot |
研究背景
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Expressed in the liver.
Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. In the human liver, the heavy chain is predominant. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Belongs to the ferritin family.
研究领域
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Organismal Systems > Digestive system > Mineral absorption.
文献引用
Application: WB Species: human Sample: HK‐2 cells
Application: WB Species: Human Sample: Human erythroleukemia cell lines (HEL)
Application: IF/ICC Species: Mouse Sample: kidney
Application: WB Species: Mouse Sample: kidney
Application: WB Species: Mouse Sample: RAW264.7 cells
Application: WB Species: Mouse Sample: GC-2 cells
Application: IHC Species: mouse Sample: heart
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