产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6459, RRID:AB_2838421.
展开/折叠
AAC1; ARY1_HUMAN; Arylamide acetylase 1; Arylamine N acetyltransferase 1; Arylamine N-acetyltransferase 1; mNAT; Monomorphic arylamine N acetyltransferase; Monomorphic arylamine N-acetyltransferase; N acetyltransferase type 1; N-acetyltransferase type 1; NAT 1; NAT-1; nat1; NATI;
抗原和靶标
- P18440 ARY1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P18440 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| Y101 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| Y208 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| T227 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| T289 | Phosphorylation | Uniprot |
研究背景
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Cytoplasm.
Belongs to the arylamine N-acetyltransferase family.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Biosynthesis of other secondary metabolites > Caffeine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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