产品: | GSTA1 抗体 |
货号: | DF6514 |
描述: | Rabbit polyclonal antibody to GSTA1 |
应用: | WB IHC |
反应: | Human, Mouse, Rat |
预测: | Pig, Bovine, Horse, Sheep, Chicken, Xenopus |
分子量: | 26kDa; 26kD(Calculated). |
蛋白号: | P08263 |
RRID: | AB_2838476 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6514, RRID:AB_2838476.
展开/折叠
Glutathione S alkyltransferase A1; Glutathione S aryltransferase A1; Glutathione S transferase 2; Glutathione S transferase A1; Glutathione S transferase alpha 1; Glutathione S transferase Ha subunit 1; Glutathione S-transferase A1; GST class-alpha member 1; GST epsilon; GST HA subunit 1; GST, class alpha, 1; GST-epsilon; GST2; GSTA1 1; GSTA1; GSTA1-1; GSTA1_HUMAN; GTH1; HA subunit 1; MGC131939; OTTHUMP00000016611; S (hydroxyalkyl)glutathione lyase A1;
抗原和靶标
- P08263 GSTA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08263 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y9 | Phosphorylation | Uniprot | |
S37 | Phosphorylation | Uniprot | |
Y49 | Phosphorylation | Uniprot | |
Y74 | Phosphorylation | Uniprot | |
S77 | Phosphorylation | Uniprot | |
Y79 | Phosphorylation | Uniprot | |
Y82 | Phosphorylation | Uniprot | |
K84 | Acetylation | Uniprot | |
K87 | Acetylation | Uniprot | |
K125 | Ubiquitination | Uniprot | |
Y132 | Phosphorylation | Uniprot | |
S142 | Phosphorylation | Uniprot | |
Y147 | Phosphorylation | Uniprot | |
K152 | Acetylation | Uniprot | |
S154 | Phosphorylation | Uniprot | |
S176 | Phosphorylation | Uniprot | |
S177 | Phosphorylation | Uniprot | |
S189 | Phosphorylation | Uniprot | |
T193 | Phosphorylation | Uniprot | |
K195 | Acetylation | Uniprot | |
K196 | Acetylation | Uniprot | |
S202 | Phosphorylation | Uniprot | |
S212 | Phosphorylation | Uniprot |
研究背景
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
Cytoplasm.
Liver.
Homodimer or heterodimer of GSTA1 and GSTA2.
The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.
Belongs to the GST superfamily. Alpha family.
研究领域
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
文献引用
Application: WB Species: mouse Sample: liver
Application: WB Species: Sample: hepatocytes
Application: WB Species: human Sample: HepG2 cells
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