ETV6 / Tel Antibody - #DF6521

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产品: ETV6 / Tel 抗体
货号: DF6521
描述: Rabbit polyclonal antibody to ETV6 / Tel
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Rabbit, Dog, Chicken, Xenopus
分子量: 53kDa; 53kD(Calculated).
蛋白号: P41212
RRID: AB_2838483

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(88%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(86%)
克隆:
Polyclonal
特异性:
ETV6 / Tel Antibody detects endogenous levels of total ETV6 / Tel.
RRID:
AB_2838483
引用格式: Affinity Biosciences Cat# DF6521, RRID:AB_2838483.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6;

抗原和靶标

免疫原:
Uniprot:

P41212(ETV6_HUMAN) >>Visit HPA database.

基因/基因ID:
ETV6(2120)
表达:
P41212 ETV6_HUMAN:

Ubiquitous.

描述:
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
序列:
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Dog
100
Chicken
100
Rabbit
100
Bovine
88
Xenopus
86
Zebrafish
67
Horse
0
Sheep
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P41212 作为底物

Site PTM Type Enzyme
S2 Phosphorylation
T4 Phosphorylation
K11 Acetylation
K11 Sumoylation
S16 Phosphorylation
Y17 Phosphorylation
T18 Phosphorylation
S22 Phosphorylation Q16539 (MAPK14)
S26 Phosphorylation
Y27 Phosphorylation
S29 Phosphorylation
S30 Phosphorylation
T31 Phosphorylation
S47 Phosphorylation
Y60 Phosphorylation
K99 Sumoylation
S131 Phosphorylation
S139 Phosphorylation
T142 Phosphorylation
T161 Phosphorylation
S165 Phosphorylation
S182 Phosphorylation
S184 Phosphorylation
T187 Phosphorylation
T188 Phosphorylation
S193 Phosphorylation
S203 Phosphorylation
S213 Phosphorylation P27361 (MAPK3)
S238 Phosphorylation
S257 Phosphorylation Q16539 (MAPK14) , P27361 (MAPK3)
S271 Phosphorylation
S284 Phosphorylation
S293 Phosphorylation
K302 Acetylation
K302 Ubiquitination
Y314 Phosphorylation
S323 Phosphorylation
K384 Ubiquitination
K393 Ubiquitination
Y401 Phosphorylation
Y402 Phosphorylation
K403 Ubiquitination
K421 Sumoylation
K421 Ubiquitination
T422 Phosphorylation
S439 Phosphorylation
Y447 Phosphorylation

研究背景

功能:

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.

翻译修饰:

Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous.

亚基结构:

Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9.

蛋白家族:

Belongs to the ETS family.

研究领域

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

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