| 产品: | ITGAL 抗体 |
| 货号: | DF6525 |
| 描述: | Rabbit polyclonal antibody to ITGAL |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 129kDa; 129kD(Calculated). |
| 蛋白号: | P20701 |
| RRID: | AB_2838487 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6525, RRID:AB_2838487.
展开/折叠
Lymphocyte function associated antigen, type 1, alpha subunit; Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide; Antigen CD11A; CD 11a; CD11 antigen-like family member A; CD11a; CD11a antigen; Integrin Alpha L; Integrin alpha-L; Integrin gene promoter; Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide); ITAL_HUMAN; Itgal; ITGAL protein; Leukocyte adhesion glycoprotein LFA 1 alpha chain; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain; Leukocyte function associated molecule 1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA 1 alpha (LFA1A); LFA 1 alpha; LFA 1; LFA 1A; LFA-1A; LFA1A; Ly15; Ly21; Lymphocyte function associated antigen 1; Lymphocyte Function Associated Antigen Type 1 alpha; lymphocyte function-associated antigen 1, alpha polypeptide; p180;
抗原和靶标
- P20701 ITAL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P20701 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| N188 | N-Glycosylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| Y332 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| K769 | Acetylation | Uniprot | |
| K769 | Ubiquitination | Uniprot | |
| K775 | Ubiquitination | Uniprot | |
| K776 | Acetylation | Uniprot | |
| K776 | Ubiquitination | Uniprot | |
| K831 | Ubiquitination | Uniprot | |
| K836 | Ubiquitination | Uniprot | |
| S839 | Phosphorylation | Uniprot | |
| K945 | Ubiquitination | Uniprot | |
| K950 | Ubiquitination | Uniprot | |
| S1140 | Phosphorylation | Uniprot | |
| S1163 | Phosphorylation | Uniprot | |
| S1165 | Phosphorylation | Uniprot |
研究背景
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Cell membrane>Single-pass type I membrane protein.
Leukocytes.
Heterodimer of an alpha and a beta subunit. The ITGAL alpha subunit associates with the ITGB2 beta subunit. Interacts with THBD.
The integrin I-domain (insert) is a VWFA domain (PubMed:2537322). Integrins with I-domains do not undergo protease cleavage. The I-domain is necessary and sufficient for interaction with ICAM1 and F11R (PubMed:15528364).
Belongs to the integrin alpha chain family.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Malaria.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Human Diseases > Immune diseases > Rheumatoid arthritis.
· Human Diseases > Cardiovascular diseases > Viral myocarditis.
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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