产品: | UGT1A9 抗体 |
货号: | DF6537 |
描述: | Rabbit polyclonal antibody to UGT1A9 |
应用: | WB IHC |
反应: | Human, Mouse, Rat |
分子量: | 60kDa; 60kD(Calculated). |
蛋白号: | O60656 |
RRID: | AB_2838499 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6537, RRID:AB_2838499.
展开/折叠
GNT1; HLUGP4; lugP4; UD19_HUMAN; UDP glucuronosyltransferase 1A9; UDP glucuronosyltransferase family 1 member A9; UDP-glucuronosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT 1-9; UDPGT; UGT-1I; UGT1*9; UGT1-09; UGT1.9; Ugt1a9; UGT1A9S; UGT1AI; UGT1I;
抗原和靶标
Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine.
- O60656 UD19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
翻译修饰 - O60656 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
N71 | N-Glycosylation | Uniprot | |
T202 | Phosphorylation | Uniprot | |
N292 | N-Glycosylation | Uniprot | |
N344 | N-Glycosylation | Uniprot | |
K434 | Acetylation | Uniprot |
研究背景
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Microsome. Endoplasmic reticulum membrane>Single-pass membrane protein.
Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine.
Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10.
Belongs to the UDP-glycosyltransferase family.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.
· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.
· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
文献引用
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