| 产品: | DUSP16 抗体 |
| 货号: | AF0522 |
| 描述: | Rabbit polyclonal antibody to DUSP16 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Rabbit, Chicken |
| 分子量: | 73kDa; 73kD(Calculated). |
| 蛋白号: | Q9BY84 |
| RRID: | AB_2833797 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0522, RRID:AB_2833797.
展开/折叠
Dual specificity phosphatase 16; Dual specificity protein phosphatase 16; DUS16_HUMAN; DUSP 16; DUSP16; KIAA1700; MAP kinase phosphatase 7; MAPK phosphatase 7; Mitogen activated protein kinase phosphatase 7; Mitogen-activated protein kinase phosphatase 7; MKP 7; MKP-7; MKP7;
抗原和靶标
- Q9BY84 DUS16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQSSQDVASLSSDCFLTVLLGKLEKSFNSVHLLAGGFAEFSRCFPGLCEGKSTLVPTCISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAASLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHRSGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVYSVRRRQKPSDRADSRRSWHEESPFEKQFKRRSCQMEFGESIMSENRSREELGKVGSQSSFSGSMEIIEVS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9BY84 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S82 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S501 | Phosphorylation | Uniprot | |
| S604 | Phosphorylation | Uniprot | |
| S609 | Phosphorylation | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot |
研究背景
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.
(Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
Cytoplasm. Nucleus. Cytoplasmic vesicle.
Note: After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
Interacts with ARRB2.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
研究领域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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