产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6613, RRID:AB_2838575.
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17 beta HSD 5; 17 beta hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 2-dihydrobenzene-1; 2-diol dehydrogenase; 20-alpha-hydroxysteroid dehydrogenase; 3 alpha hydroxysteroid dehydrogenase type II; 3-alpha-HSD type 2; 3-alpha-HSD type II; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; AK1C3_HUMAN; AKR1 C3; Akr1c18; AKR1C3; Aldo keto reductase family 1 member C3; Aldo-keto reductase family 1 member C3; brain; Chlordecone reductase; Chlordecone reductase homolog HAKRb; DD-3; DD3; DDH1; DDX; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase X; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; Indanol dehydrogenase; KIAA0119; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; Trans-1; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Type IIb 3 alpha hydroxysteroid dehydrogenase;
抗原和靶标
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
- P42330 AK1C3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY
翻译修饰 - P42330 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K9 | Sumoylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K75 | Acetylation | Uniprot | |
| K75 | Sumoylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K105 | Acetylation | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| K209 | Acetylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| K246 | Acetylation | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| K247 | Acetylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K270 | Acetylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| Y319 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| Y323 | Phosphorylation | Uniprot |
研究背景
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Cytoplasm.
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Belongs to the aldo/keto reductase family.
研究领域
· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.
· Metabolism > Lipid metabolism > Arachidonic acid metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Ovarian steroidogenesis.
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