| 产品: | XRCC2 抗体 |
| 货号: | DF6624 |
| 描述: | Rabbit polyclonal antibody to XRCC2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 32kDa; 32kD(Calculated). |
| 蛋白号: | O43543 |
| RRID: | AB_2838586 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6624, RRID:AB_2838586.
展开/折叠
DKFZp781P0919; DNA repair protein XRCC2; X ray repair complementing defective repair in Chinese hamster cells 2; X ray repair cross complementing protein 2; X-ray repair cross-complementing protein 2; Xrcc2; XRCC2_HUMAN;
抗原和靶标
- O43543 XRCC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCSAFHRAESGTELLARLEGRSSLKEIEPNLFADEDSPVHGDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSKQDDSQSSNQFSLVSRCLKSNSLKKHFFIIGESGVEFC
翻译修饰 - O43543 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| T12 | Phosphorylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| Y59 | Phosphorylation | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| K261 | Ubiquitination | Uniprot |
研究背景
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.
Belongs to the RecA family. RAD51 subfamily.
研究领域
· Genetic Information Processing > Replication and repair > Homologous recombination.
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