| 产品: | THPO 抗体 |
| 货号: | DF6640 |
| 描述: | Rabbit polyclonal antibody to THPO |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Horse, Sheep |
| 分子量: | 38kDa; 38kD(Calculated). |
| 蛋白号: | P40225 |
| RRID: | AB_2838602 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6640, RRID:AB_2838602.
展开/折叠
C mpl ligand; C-mpl ligand; Megakaryocyte colony stimulating factor; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; Prepro thrombopoietin; THCYT1; THPO; Thrombopoietin; Thrombopoietin nirs variant 1; TPO; TPO_HUMAN;
抗原和靶标
- P40225 TPO_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P40225 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S22 | O-Glycosylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| T58 | O-Glycosylation | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| T131 | O-Glycosylation | Uniprot | |
| T179 | O-Glycosylation | Uniprot | |
| T180 | O-Glycosylation | Uniprot | |
| S184 | O-Glycosylation | Uniprot | |
| N197 | N-Glycosylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| N206 | N-Glycosylation | Uniprot | |
| T213 | O-Glycosylation | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| N234 | N-Glycosylation | Uniprot | |
| N255 | N-Glycosylation | Uniprot | |
| S265 | O-Glycosylation | Uniprot |
研究背景
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Secreted.
Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
Belongs to the EPO/TPO family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
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