IL2RG Antibody - #DF6642

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产品: IL2RG 抗体
货号: DF6642
描述: Rabbit polyclonal antibody to IL2RG
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Dog
分子量: 42kDa; 42kD(Calculated).
蛋白号: P31785
RRID: AB_2838604

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(90%), Bovine(100%), Sheep(100%), Dog(90%)
克隆:
Polyclonal
特异性:
IL2RG Antibody detects endogenous levels of total IL2RG.
RRID:
AB_2838604
引用格式: Affinity Biosciences Cat# DF6642, RRID:AB_2838604.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD132; CD132 antigen; CIDX; common cytokine receptor gamma chain; Cytokine receptor common subunit gamma; Gamma C; gamma(c); gammaC; IL-2 receptor subunit gamma; IL-2R gamma chain; IL-2R subunit gamma; IL-2RG; Il2rg; IL2RG_HUMAN; IMD4; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1;

抗原和靶标

免疫原:
Uniprot:

P31785(IL2RG_HUMAN) >>Visit HPA database.

基因/基因ID:
IL2RG(3561)
描述:
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
序列:
MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Bovine
100
Sheep
100
Pig
90
Dog
90
Rabbit
43
Horse
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P31785 作为底物

Site PTM Type Enzyme
N71 N-Glycosylation
N84 N-Glycosylation
K101 Ubiquitination
K119 Ubiquitination
K147 Ubiquitination
N159 N-Glycosylation
K164 Ubiquitination
K207 Ubiquitination
K217 Ubiquitination
T292 Phosphorylation
K294 Ubiquitination
T301 Phosphorylation
Y303 Phosphorylation
S308 Phosphorylation
K315 Ubiquitination
S320 Phosphorylation
Y325 Phosphorylation
S326 Phosphorylation
Y357 Phosphorylation
Y363 Phosphorylation

研究背景

功能:

Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.

细胞定位:

Cell membrane>Single-pass type I membrane protein. Cell surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation.

(Microbial infection) Interacts with HTLV-1 accessory protein p12I.

蛋白家族:

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Belongs to the type I cytokine receptor family. Type 5 subfamily.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).

· Human Diseases > Immune diseases > Primary immunodeficiency.

· Organismal Systems > Immune system > Th1 and Th2 cell differentiation.   (View pathway)

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

文献引用

1). Alleviating CB2-Dependent ER Stress and Mitochondrial Dysfunction Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2024 (PubMed: 38214766) [IF=6.2]

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